Biofunctionalized surfaces & materials for medical applications
发布部门:化学化工与生物工程学院       发布时间:2019-11-26


Dr. Xin Xiong (born on Dec. 6th, 1977, Dalian) graduated from the University of Stuttgart with a diplom-degree in "Technical Biology" with a focus on "Microbial Biotechnology" and a PhD from the Fraunhofer IGB in collagen-based biomaterials and infection models (Dept. of Molecular Biotechnology). Since his diplom thesis he works at the interface between biology and materials science with medical relevance. Since 2011 he is employed as a scientist at the NMI Reutlingen in the group Biomaterials. Since 2017 he has been taking over the group management of the Group of Biofunctionalized Surfaces at the NMI.

In numerous application-oriented projects, funded by industry and the public sector, the group is working with industry partners to develop coatings and biomaterials for medical applications.

Since 2012 Dr. Xiong coordinates the cooperation with Chinese universities and contracted research projects from Chinese companies at the NMI. He supports German SMEs with the CFDA approval. Since 2014, several class II and III medical devices have been approved by the CFDA.

Together with Prof. Dr. Rolf Schmid, he worked on the country and industry study "Medical Biotechnology Profiling China" of the Federal Ministry of Economics (BMWi) in 2017 and since July 2018 they are writing the monthly newsletters about the Chinese market for pharmaceuticals and medical devices in contract from the export initiative Trade and Invest (GTAI) at the BMWi.

Since 2015, he was involved in the lectures for Master students in the faculty of applied chemistry at the Reutlingen University (regulatory affairs, microbiology and drug delivery systems). He is also collaborating in numerous public funded industrial oriented research projects with several groups of the faculty.


In recent years microfluidic devices became of great interest, as they offer a wide range of bio-analytical and fluid processing applications through the utilization of size effects. Especially a mass manufacturing of disposable polymeric microfluidic devices by hot embossing or injection molding is expected to have high economic potential. It is known, that channels and areas showing a localized change in wettability can considerably improve fluid processing tasks like mixing or droplet generation. Chemical approaches, like the polymerization of lauryl acrylate, were successfully shown to achieve hydrophobic coatings for micro channels but are not suitable for a mass manufacturing. Since microstructures are known to provide water repellent properties of surfaces, this paper focuses on the applicability of diamond grooving and Diamond Micro Chiseling (DMC) processes for the manufacture of microstructured areas in brass molds inserts, in order to achieve hydrophobic properties of their replica. Major design features of structures, like a height range of 6 to 16μm or aspect ratios in between 0.5 and 3.2 are derived from the natural example of the lotus leaf. Molding is carried out by using a two component silicone filler. The performance of the replicated hydrophobic surfaces is evaluated by droplet contact angle measurements. After presenting methodology and results, the paper will conclude on how to transfer the investigated microstructuring methods to the manufacture of mold inserts for the replication of polymeric microfluidic chips with localized hydrophobic areas and channels